![]() The Clock Drawing Test (CDT) is a widely used assessment tool able to screen for impairment associated with mild cognitive impairment (MCI) and dementia. The dCDT has the potential to be used as a cognitive assessment tool in the clinical diagnosis of MCI. The classification model for differentiating MCI and normal cognition participants, which incorporated age, sex, education, MRI measures, and dCDT composite scores, showed an area under the curve of 0.897.Ĭonclusions: dCDT composite scores were significantly associated with multiple brain MRI measures in a large community-based cohort. None of the dCDT composite scores was associated with hippocampal volume or WMH volume. Eleven dCDT composite scores were associated with cerebral white matter volume, but only 1 dCDT composite score was associated with cerebral gray matter volume. All dCDT composite scores were associated with TCBV after adjusting for multiple testing ( P value <.05/18). Results: A total of 1656 participants were included in this study (mean age 61 years, SD 13 years 50.9% women), with 23 participants diagnosed with MCI. Classification models were also built from clinical risk factors, dCDT composite scores, and MRI measures to distinguish people with mild cognitive impairment (MCI) from those whose cognition was intact. ![]() Linear regression models were used to assess the association between 18 dCDT composite scores (derived from 105 dCDT raw features) and brain MRI measures, including total cerebral brain volume (TCBV), cerebral white matter volume, cerebral gray matter volume, hippocampal volume, and white matter hyperintensity (WMH) volume. Methods: This study included participants from the Framingham Heart Study who had both a dCDT and magnetic resonance imaging (MRI) scan, and were free of dementia or stroke. Objective: We aimed to investigate the association between dCDT features and brain volume. However, the association between digitally obtained clock drawing features and structural neuroimaging measures has not been assessed in large population-based studies. University of Massachusetts Chan Medical SchoolĮmail: The digital Clock Drawing Test (dCDT) has been recently used as a more objective tool to assess cognition. JMIR Bioinformatics and Biotechnology 23 articlesġDepartment of Neurology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, ChinaĢDepartment of Anatomy and Neurobiology, Boston University School of Medicine, Boston University, Boston, MA, United StatesģFramingham Heart Study, Boston University School of Medicine, Boston University, Boston, MA, United StatesĤDepartment of Neurology, Boston University School of Medicine, Boston University, Boston, MA, United StatesĥDepartment of Epidemiology, Boston University School of Public Health, Boston University, Boston, MA, United StatesĦSlone Epidemiology Center, Boston University School of Medicine, Boston University, Boston, MA, United StatesħAlzheimer’s Disease Research Center, Boston University, Boston, MA, United StatesĨDepartment of Neurology and Center for Neuroscience, University of California, Davis, Sacramento, CA, United StatesĩDepartment of Geriatrics and Gerontology and Department of Psychology, New Jersey Institute for Successful Aging, Rowan University, School of Osteopathic Medicine, Stratford, NJ, United Statesġ0Division of Clinical Informatics, Department of Medicine, University of Massachusetts Chan Medical School, Worcester, MA, United States.JMIR Biomedical Engineering 61 articles.JMIR Perioperative Medicine 69 articles.Journal of Participatory Medicine 71 articles.JMIR Rehabilitation and Assistive Technologies 177 articles.JMIR Pediatrics and Parenting 230 articles.Interactive Journal of Medical Research 259 articles.JMIR Public Health and Surveillance 964 articles.Journal of Medical Internet Research 6898 articles. ![]()
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